PEG-MGF 5mgPEG-MGF 5mg

Description

PEG-MGF 5mg

(Note: This product is a larger size than the standard 2mg typically sold.)

Overview

Pegylated Mechano-Growth Factor (PEG-MGF) is a modified form of insulin-like growth factor-1 (IGF-1), specifically derived from the IGF-1 Ec splice variant. Through pegylation – the attachment of polyethylene glycol (PEG) – the stability and circulation time of the native peptide are greatly enhanced.

This modification reduces renal clearance and shields the peptide from enzymatic breakdown, resulting in a longer biological half-life and improved experimental reliability. PEG-MGF is widely used in growth-factor, muscle-adaptation, and cell-recovery research, helping scientists investigate how cells respond to physical or mechanical stress.

Scientific Background

Mechano-Growth Factor (MGF) is a naturally occurring isoform of IGF-1, expressed in response to mechanical loading or tissue damage. It has been studied for its role in initiating muscle-cell repair and regeneration.

Because unmodified MGF degrades rapidly in the body, researchers developed PEG-MGF to improve its half-life and maintain activity over extended observation periods. This allows for more consistent data and the possibility to study prolonged growth-factor signalling effects.

Mechanism of Action

PEG-MGF interacts with the IGF-1 receptor pathway, triggering several key intracellular responses:

• Satellite-cell activation and myogenic differentiation

• Protein-synthesis stimulation through the PI3K/Akt/mTOR cascade

• Cellular repair and recovery following physical or metabolic stress

• Tissue adaptation linked to mechanical overload

The pegylated modification enables PEG-MGF to remain active for longer than native MGF, offering researchers valuable opportunities to examine long-term anabolic signalling.

Research Focus Areas

1. Muscle Repair and Regeneration – Investigating PEG-MGF’s ability to stimulate satellite-cell proliferation and muscle-fibre recovery.

2. Growth-Factor Signalling – Studying sustained activation of the IGF-1 receptor and downstream anabolic pathways.

3. Cellular Recovery Mechanisms – Exploring the peptide’s contribution to tissue healing and adaptation after mechanical or oxidative stress.

4. Extended-Stability Comparisons – Comparing pegylated and non-pegylated peptides to understand differences in bioavailability and duration of activity.

Technical Details

• Synonyms: Pegylated MGF, PEG IGF-1 Ec, PEG Myotrophin
• Sequence: PEG-Suc-YQPPSTNKNTKSQ(d-R)(d-R)KGSTFEEHK-NH₂
• IUPAC Condensed: PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH₂
• Molecular Weight: Variable due to PEG modification
• CAS Number: Not individually assigned (variant of IGF-1 Ec)
• PubChem CID: 178101669

Stability and Storage

Store lyophilised protein at –20 °C.
After reconstitution, aliquot to prevent repeated freeze–thaw cycles.
Reconstituted solution may be stored at 4 °C for short-term use.
The lyophilised peptide remains stable until its expiry date when kept at –20 °C.

Source and Reconstitution

Source: Biosynthesis
Reconstitution: Reconstitute with Bacteriostatic Water