NAD+ 500mg

Description

NAD+ Supplement – 500mg

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in all living cells, composed of nicotinamide, adenine, ribose sugars, and phosphate groups. It plays a central role as a redox carrier, cycling between its oxidized (NAD+) and reduced (NADH) forms to drive essential metabolic reactions. Supplied as a high-purity, research-grade 500 mg powder, NAD⁺ is intended exclusively for laboratory use in studies exploring cellular metabolism, redox regulation, and enzymatic processes. This compound is strictly for research use only and not for medical or therapeutic applications.

Research Focus and Areas of Interest

1. Metabolic Regulation

NAD+ is essential for metabolic processes including glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. It functions as an electron acceptor, facilitating the flow of energy within cells. Researchers studying cellular energy dynamics or testing metabolic flux in various model systems often supplement with NAD+ to assess redox balance and energy output in controlled experimental settings.

2. Enzyme–Cofactor Interactions

As a cofactor, NAD+ is required by numerous enzymes such as sirtuins, dehydrogenases, and PARPs (poly ADP-ribose polymerases). These enzymes are involved in a wide range of cellular processes, including DNA repair, chromatin remodeling, and protein post-translational modifications. Laboratory studies using NAD+ allow researchers to isolate and quantify its interactions in enzymatic assays or reconstituted biochemical systems.

3. Redox Homeostasis and ROS Signaling

In redox biology, NAD+ is used to investigate the cellular response to oxidative stress and reactive oxygen species (ROS). By modulating NAD+ concentrations, researchers can explore redox-sensitive pathways, antioxidant responses, and mitochondrial signaling, particularly in studies modelling stress-induced cell behavior or oxidative imbalance.

4. Neuroscience and Neuromodulation

NAD+ is increasingly studied in the context of neuronal energy metabolism and neuroprotective mechanisms. Researchers exploring synaptic activity, mitochondrial health in neurons, and neuromodulatory pathways often utilize NAD+ in ex vivo preparations or neuronal cultures to better understand how it supports metabolic maintenance and signaling under stress.

5. Cellular Senescence and Longevity Models

NAD+ is frequently examined in cellular aging and senescence models due to its role in maintaining metabolic integrity and genomic stability. Experimental systems designed to mimic age-related cellular changes often include NAD+ supplementation to monitor shifts in energy metabolism, stress tolerance, or sirtuin activity during culture-induced aging.

Conclusion

NAD+ (500 mg) offers a reliable and high-purity option for researchers engaged in diverse fields such as metabolism, redox biology, enzymology, and neuroscience. With its broad relevance across biological systems, NAD+ continues to be a compound of significant interest in advancing understanding of cellular energy, oxidative regulation, and molecular stability. Supplied as a powder and marked strictly for research use only, it is not intended for human or veterinary applications.

Technical Information:

• Synonyms: Nicotinamide Adenine Dinucleotide (oxidized form), NAD⁺

• IUPAC Name: β-Nicotinamide adenine dinucleotide

• Molecular Formula: C₂₁H₂₇N₇O₁₄P

• Molecular Weight: 663.43 g/mol

• CAS Number: 53‑84‑9

• PubChem CID: 439174

• Further References: PubChem Entry